Trends Identified

Video games are the new social media

At over 2.3 billion, Facebook has by far more users than any social media platform worldwide (Twitter, by comparison, has about 325 million). That’s why, despite its increasingly tattered reputation, Facebook continues to be popular with advertisers in search of eyeballs. At the same time, Facebook has a problem with young people, with only about half of all high-school aged kids being active on the platform. If young people are not using Facebook now, what makes anyone believe that they’ll log on when they get older? They most likely won't, and a big reason why is video games. Thanks partly to the rousing success of “Fortnite,” Amazon-owned Twitch and other platforms like it are creating communities that young people prize far more than Facebook, whether they are watching their favorite gamers or facing off with their friends or with others across the globe. These types of immersive experiences dwarf anything Facebook offers this group, calling into question whether the company can sustain its advertising prowess in the years to come as the younger generation becomes a highly sought-after consumer demographic. Underscoring this dynamic is Netflix, which said in its most recent shareholder letter that it competes more with “Fortnite” than it does HBO. Skeptics will scoff at that, pointing out (correctly) even the biggest phenomenon fade at some point. However, the next huge game is just around the corner, and when it arrives, Netflix, along with social media, will have to worry about it cannibalizing users too. All this is good news for gaming companies, including Tencent, whose subsidiary, Epic Games, published “Fortnite,” Electronic Arts and Activision.

2019

Three Big Tech Trends For 2019

Forbes

Autonomous driving and artificial intelligence

The future of transportation will branch in two directions. One is the Waymo approach, which essentially seeks to remove human drivers from the equation, leaving us with almost an AI-powered Uber alternative. The other is exemplified by Tesla, which is infusing manned vehicles with a series of innovative autonomous features. Each will be here quicker than most realize. One of the reasons is that advances in artificial intelligence are driven, in part, by the availability of more data, so with each new Tesla or Waymo test vehicle that hits the road, semi-autonomous and autonomous capabilities grow exponentially. This is especially true for Tesla’s systems, thanks to the company delivering almost as many cars last year as all previous years combined. AI-enabled transportation is yet another area where investors have an excellent opportunity to back chip makers Nvidia and Intel, whose valuations in recent months have become far more reasonable due to trade-related issues that will likely dissipate going forward. As we move to the next level of internet, entertainment and transportation, there will be huge opportunities for the companies that are best positioned to take advantage of the new technology trends. Investors should take notice.

2019

Three Big Tech Trends For 2019

Forbes

Robot dexterity

Robots are teaching themselves to handle the physical world.For all the talk about machines taking jobs, industrial robots are still clumsy and inflexible. A robot can repeatedly pick up a component on an assembly line with amazing precision and without ever getting bored—but move the object half an inch, or replace it with something slightly different, and the machine will fumble ineptly or paw at thin air. But while a robot can’t yet be programmed to figure out how to grasp any object just by looking at it, as people do, it can now learn to manipulate the object on its own through virtual trial and error. One such project is Dactyl, a robot that taught itself to flip a toy building block in its fingers. Dactyl, which comes from the San Francisco nonprofit OpenAI, consists of an off-the-shelf robot hand surrounded by an array of lights and cameras. Using what’s known as reinforcement learning, neural-network software learns how to grasp and turn the block within a simulated environment before the hand tries it out for real. The software experiments, randomly at first, strengthening connections within the network over time as it gets closer to its goal. It usually isn’t possible to transfer that type of virtual practice to the real world, because things like friction or the varied properties of different materials are so difficult to simulate. The OpenAI team got around this by adding randomness to the virtual training, giving the robot a proxy for the messiness of reality. We’ll need further breakthroughs for robots to master the advanced dexterity needed in a real warehouse or factory. But if researchers can reliably employ this kind of learning, robots might eventually assemble our gadgets, load our dishwashers, and even help Grandma out of bed. —Will Knight

2019

10 Breakthrough Technologies 2019 - How we’ll invent the future, by Bill Gates

MIT Technology Review

New-wave nuclear power

Advanced fusion and fission reactors are edging closer to reality. New nuclear designs that have gained momentum in the past year are promising to make this power source safer and cheaper. Among them are generation IV fission reactors, an evolution of traditional designs; small modular reactors; and fusion reactors, a technology that has seemed eternally just out of reach. Developers of generation IV fission designs, such as Canada’s Terrestrial Energy and Washington-based TerraPower, have entered into R&D partnerships with utilities, aiming for grid supply (somewhat optimistically, maybe) by the 2020s. Small modular reactors typically produce in the tens of megawatts of power (for comparison, a traditional nuclear reactor produces around 1,000 MW). Companies like Oregon’s NuScale say the miniaturized reactors can save money and reduce environmental and financial risks. There has even been progress on fusion. Though no one expects delivery before 2030, companies like General Fusion and Commonwealth Fusion Systems, an MIT spinout, are making some headway. Many consider fusion a pipe dream, but because the reactors can’t melt down and don’t create long-lived, high-level waste, it should face much less public resistance than conventional nuclear. (Bill Gates is an investor in TerraPower and Commonwealth Fusion Systems.) —Leigh Phillips

2019

10 Breakthrough Technologies 2019 - How we’ll invent the future, by Bill Gates

MIT Technology Review

Predicting preemies

A simple blood test can predict if a pregnant woman is at risk of giving birth prematurely. Our genetic material lives mostly inside our cells. But small amounts of “cell-free” DNA and RNA also float in our blood, often released by dying cells. In pregnant women, that cell-free material is an alphabet soup of nucleic acids from the fetus, the placenta, and the mother. Stephen Quake, a bioengineer at Stanford, has found a way to use that to tackle one of medicine’s most intractable problems: the roughly one in 10 babies born prematurely. Free-floating DNA and RNA can yield information that previously required invasive ways of grabbing cells, such as taking a biopsy of a tumor or puncturing a pregnant woman’s belly to perform an amniocentesis. What’s changed is that it’s now easier to detect and sequence the small amounts of cell-free genetic material in the blood. In the last few years researchers have begun developing blood tests for cancer (by spotting the telltale DNA from tumor cells) and for prenatal screening of conditions like Down syndrome. The tests for these conditions rely on looking for genetic mutations in the DNA. RNA, on the other hand, is the molecule that regulates gene expression—how much of a protein is produced from a gene. By sequencing the free-floating RNA in the mother’s blood, Quake can spot fluctuations in the expression of seven genes that he singles out as associated with preterm birth. That lets him identify women likely to deliver too early. Once alerted, doctors can take measures to stave off an early birth and give the child a better chance of survival. The technology behind the blood test, Quake says, is quick, easy, and less than $10 a measurement. He and his collaborators have launched a startup, Akna Dx, to commercialize it. —Bonnie Rochman

2019

10 Breakthrough Technologies 2019 - How we’ll invent the future, by Bill Gates

MIT Technology Review

Gut probe in a pill

A small, swallowable device captures detailed images of the gut without anesthesia, even in infants and children. Environmental enteric dysfunction (EED) may be one of the costliest diseases you’ve never heard of. Marked by inflamed intestines that are leaky and absorb nutrients poorly, it’s widespread in poor countries and is one reason why many people there are malnourished, have developmental delays, and never reach a normal height. No one knows exactly what causes EED and how it could be prevented or treated. Practical screening to detect it would help medical workers know when to intervene and how. Therapies are already available for infants, but diagnosing and studying illnesses in the guts of such young children often requires anesthetizing them and inserting a tube called an endoscope down the throat. It’s expensive, uncomfortable, and not practical in areas of the world where EED is prevalent. So Guillermo Tearney, a pathologist and engineer at Massachusetts General Hospital (MGH) in Boston, is developing small devices that can be used to inspect the gut for signs of EED and even obtain tissue biopsies. Unlike endoscopes, they are simple to use at a primary care visit. Tearney’s swallowable capsules contain miniature microscopes. They’re attached to a flexible string-like tether that provides power and light while sending images to a briefcase-like console with a monitor. This lets the health-care worker pause the capsule at points of interest and pull it out when finished, allowing it to be sterilized and reused. (Though it sounds gag-­inducing, Tearney’s team has developed a technique that they say doesn’t cause discomfort.) It can also carry technologies that image the entire surface of the digestive tract at the resolution of a single cell or capture three-dimensional cross sections a couple of millimeters deep. The technology has several applications; at MGH it’s being used to screen for Barrett’s esophagus, a precursor of esophageal cancer. For EED, Tearney’s team has developed an even smaller version for use in infants who can’t swallow a pill. It’s been tested on adolescents in Pakistan, where EED is prevalent, and infant testing is planned for 2019.The little probe will help researchers answer questions about EED’s development—such as which cells it affects and whether bacteria are involved—and evaluate interventions and potential treatments. —Courtney Humphries

2019

10 Breakthrough Technologies 2019 - How we’ll invent the future, by Bill Gates

MIT Technology Review

Custom cancer vaccines

The treatment incites the body’s natural defenses to destroy only cancer cells by identifying mutations unique to each tumor. Scientists are on the cusp of commercializing the first personalized cancer vaccine. If it works as hoped, the vaccine, which triggers a person’s immune system to identify a tumor by its unique mutations, could effectively shut down many types of cancers. By using the body’s natural defenses to selectively destroy only tumor cells, the vaccine, unlike conventional chemotherapies, limits damage to healthy cells. The attacking immune cells could also be vigilant in spotting any stray cancer cells after the initial treatment. The possibility of such vaccines began to take shape in 2008, five years after the Human Genome Project was completed, when geneticists published the first sequence of a cancerous tumor cell. Soon after, investigators began to compare the DNA of tumor cells with that of healthy cells—and other tumor cells. These studies confirmed that all cancer cells contain hundreds if not thousands of specific mutations, most of which are unique to each tumor. A few years later, a German startup called BioNTech provided compelling evidence that a vaccine containing copies of these mutations could catalyze the body’s immune system to produce T cells primed to seek out, attack, and destroy all cancer cells harboring them. In December 2017, BioNTech began a large test of the vaccine in cancer patients, in collaboration with the biotech giant Genentech. The ongoing trial is targeting at least 10 solid cancers and aims to enroll upwards of 560 patients at sites around the globe. The two companies are designing new manufacturing techniques to produce thousands of personally customized vaccines cheaply and quickly. That will be tricky because creating the vaccine involves performing a biopsy on the patient’s tumor, sequencing and analyzing its DNA, and rushing that information to the production site. Once produced, the vaccine needs to be promptly delivered to the hospital; delays could be deadly. —Adam Piore

2019

10 Breakthrough Technologies 2019 - How we’ll invent the future, by Bill Gates

MIT Technology Review

The cow-free burger

Both lab-grown and plant-based alternatives approximate the taste and nutritional value of real meat without the environmental devastation. The UN expects the world to have 9.8 billion people by 2050. And those people are getting richer. Neither trend bodes well for climate change—especially because as people escape poverty, they tend to eat more meat. By that date, according to the predictions, humans will consume 70% more meat than they did in 2005. And it turns out that raising animals for human consumption is among the worst things we do to the environment. Depending on the animal, producing a pound of meat protein with Western industrialized methods requires 4 to 25 times more water, 6 to 17 times more land, and 6 to 20 times more fossil fuels than producing a pound of plant protein.The problem is that people aren’t likely to stop eating meat anytime soon. Which means lab-grown and plant-based alternatives might be the best way to limit the destruction. Making lab-grown meat involves extracting muscle tissue from animals and growing it in bioreactors. The end product looks much like what you’d get from an animal, although researchers are still working on the taste. Researchers at Maastricht University in the Netherlands, who are working to produce lab-grown meat at scale, believe they'll have a lab-grown burger available by next year. One drawback of lab-grown meat is that the environmental benefits are still sketchy at best—a recent World Economic Forum report says the emissions from lab-grown meat would be only around 7% less than emissions from beef production. The better environmental case can be made for plant-based meats from companies like Beyond Meat and Impossible Foods (Bill Gates is an investor in both companies), which use pea proteins, soy, wheat, potatoes, and plant oils to mimic the texture and taste of animal meat. Beyond Meat has a new 26,000-square-foot (2,400-square-meter) plant in California and has already sold upwards of 25 million burgers from 30,000 stores and restaurants. According to an analysis by the Center for Sustainable Systems at the University of Michigan, a Beyond Meat patty would probably generate 90% less in greenhouse-gas emissions than a conventional burger made from a cow. —Markkus Rovito

2019

10 Breakthrough Technologies 2019 - How we’ll invent the future, by Bill Gates

MIT Technology Review

Carbon dioxide catcher

Practical and affordable ways to capture carbon dioxide from the air can soak up excess greenhouse-gas emissions. Even if we slow carbon dioxide emissions, the warming effect of the greenhouse gas can persist for thousands of years. To prevent a dangerous rise in temperatures, the UN’s climate panel now concludes, the world will need to remove as much as 1 trillion tons of carbon dioxide from the atmosphere this century. In a surprise finding last summer, Harvard climate scientist David Keith calculated that machines could, in theory, pull this off for less than $100 a ton, through an approach known as direct air capture. That’s an order of magnitude cheaper than earlier estimates that led many scientists to dismiss the technology as far too expensive—though it will still take years for costs to fall to anywhere near that level. But once you capture the carbon, you still need to figure out what to do with it. Carbon Engineering, the Canadian startup Keith cofounded in 2009, plans to expand its pilot plant to ramp up production of its synthetic fuels, using the captured carbon dioxide as a key ingredient. (Bill Gates is an investor in Carbon Engineering.) Zurich-based Climeworks’s direct air capture plant in Italy will produce methane from captured carbon dioxide and hydrogen, while a second plant in Switzerland will sell carbon dioxide to the soft-drinks industry. So will Global Thermostat of New York, which finished constructing its first commercial plant in Alabama last year. Still, if it’s used in synthetic fuels or sodas, the carbon dioxide will mostly end up back in the atmosphere. The ultimate goal is to lock greenhouse gases away forever. Some could be nested within products like carbon fiber, polymers, or concrete, but far more will simply need to be buried underground, a costly job that no business model seems likely to support.In fact, pulling CO2 out of the air is, from an engineering perspective, one of the most difficult and expensive ways of dealing with climate change. But given how slowly we’re reducing emissions, there are no good options left. —James Temple

2019

10 Breakthrough Technologies 2019 - How we’ll invent the future, by Bill Gates

MIT Technology Review

An ECG on your wrist

Regulatory approval and technological advances are making it easier for people to continuously monitor their hearts with wearable devices. Fitness trackers aren’t serious medical devices. An intense workout or loose band can mess with the sensors that read your pulse. But an electrocardiogram—the kind doctors use to diagnose abnormalities before they cause a stroke or heart attack— requires a visit to a clinic, and people often fail to take the test in time. ECG-enabled smart watches, made possible by new regulations and innovations in hardware and software, offer the convenience of a wearable device with something closer to the precision of a medical one. An Apple Watch–compatible band from Silicon Valley startup AliveCor that can detect atrial fibrillation, a frequent cause of blood clots and stroke, received clearance from the FDA in 2017. Last year, Apple released its own FDA-cleared ECG feature, embedded in the watch itself. The health-device company Withings also announced plans for an ECG-equipped watch shortly after. Current wearables still employ only a single sensor, whereas a real ECG has 12. And no wearable can yet detect a heart attack as it’s happening. But this might change soon. Last fall, AliveCor presented preliminary results to the American Heart Association on an app and two-­sensor system that can detect a certain type of heart attack. —Karen Hao

2019

10 Breakthrough Technologies 2019 - How we’ll invent the future, by Bill Gates

MIT Technology Review