Trends Identified
Precise drug delivery through nanoscale engineering
Pharmaceuticals that can be precisely delivered at the molecular level within or around a diseased cell offer unprecedented opportunities for more effective treatments while reducing unwanted side effects. Targeted nanoparticles that adhere to diseased tissue allow for the micro-scale delivery of potent therapeutic compounds while minimizing their impact on healthy tissue, and are now advancing in medical trials. After almost a decade of research, these new approaches are finally showing signs of clinical utility.
2013
The top 10 emerging technologies for 2013
World Economic Forum (WEF)
Precise genetic-engineering techniques
Conventional genetic engineering has long caused controversy. However, new techniques are emerging that allow us to directly “edit” the genetic code of plants to make them, for example, more nutritious or better able to cope with a changing climate. Currently, the genetic engineering of crops relies on the bacterium agrobacterium tumefaciens to transfer desired DNA into the target genome. The technique is proven and reliable, and despite widespread public fears, there is a consensus in the scientific community that genetically modifying organisms using this technique is no more risky than modifying them using conventional breeding. However, while agrobacterium is useful, more precise and varied genome-editing techniques have been developed in recent years.These include ZFNs, TALENS and, more recently, the CRISPR-Cas9 system, which evolved in bacteria as a defence mechanism against viruses. CRISPR-Cas9 system uses an RNA molecule to target DNA, cutting to a known, user-selected sequence in the target genome. This can disable an unwanted gene or modify it in a way that is functionally indistinguishable from a natural mutation. Using “homologous recombination”, CRISPR can also be used to insert new DNA sequences, or even whole genes, into the genome in a precise way. Another aspect of genetic engineering that appears poised for a major advance is the use of RNA interference (RNAi) in crops. RNAi is effective against viruses and fungal pathogens, and can also protect plants against insect pests, reducing the need for chemical pesticides. Viral genes have been used to protect papaya plants against the ringspot virus, for example, with no sign of resistance evolving in over a decade of use in Hawaii. RNAi may also benefit major staple-food crops, protecting wheat against stem rust, rice against blast, potato against blight and banana against fusarium wilt. Many of these innovations will be particularly beneficial to smaller farmers in developing countries. As such, genetic engineering may become less controversial, as people recognize its effectiveness at boosting the incomes and improving the diets of millions of people. In addition, more precise genome editing may allay public fears, especially if the resulting plant or animal is not considered transgenic because no foreign genetic material is introduced. Taken together, these techniques promise to advance agricultural sustainability by reducing input use in multiple areas, from water and land to fertilizer, while also helping crops to adapt to climate change.
2015
Top 10 emerging technologies of 2015
World Economic Forum (WEF)
Precision agriculture
Precision Agriculture (PA) is a farming management concept. It aims to optimise returns on inputs, including machinery, labour, chemicals, water and energy, whilst potentially reducing environmental impacts and enhancing food safety. The concept is based upon observing, measuring and responding to inter and intrafield variability in crops, or to aspects of animal husbandry. The technology offers opportunity to stimulate co-innovation, strengthen competitiveness and to contribute to a more climate and eco-smart farming. PA is seen as an important route to 'sustainable intensification'.
2015
Preparing the Commission for future opportunities - Foresight network fiches 2030
European Strategy and Policy Analysis System (ESPAS)
Precision Agriculture
Example of Organizationsactive in the area:2 Blue River Technology (US), Hortau (Canada).
2018
Table of disruptive technologies
Imperial College London
Precision Extinction
AI-piloted drone ships wipe out a large proportion of global fish stocks
2018
The Global Risks Report 2018
World Economic Forum (WEF)
Precision farming
The Fourth Industrial Revolution is providing farmers with a new set of tools to boost crop yield and quality while reducing water and chemical use. Sensors, robots, GPS, mapping tools and data-analytics software are all being used to customize the care that plants need. While the prospect of using drones to capture plant health in real time may be some way off for most of the world’s farmers, low-tech techniques are coming online too. Salah Sukkarieh, of the University of Sydney, for instance, has demonstrated a streamlined, low-cost monitoring system in Indonesia that relies on solar power and cell phones.
2017
These are the top 10 emerging technologies of 2017
World Economic Forum (WEF)
Predictable Disruption
Every business now understands the transformational power of digital. What few, though, have grasped is quite how dramatic and ongoing the changes arising from new platformbased ecosystems will be. It’s not just business models that will be turned on their heads. As these ecosystems produce powerful, predictable disruption, whole industries and economic segments will be utterly redefined and reinvented.
2016
Accenture Technology Vision 2016
Accenture
Predicting preemies
A simple blood test can predict if a pregnant woman is at risk of giving birth prematurely. Our genetic material lives mostly inside our cells. But small amounts of “cell-free” DNA and RNA also float in our blood, often released by dying cells. In pregnant women, that cell-free material is an alphabet soup of nucleic acids from the fetus, the placenta, and the mother. Stephen Quake, a bioengineer at Stanford, has found a way to use that to tackle one of medicine’s most intractable problems: the roughly one in 10 babies born prematurely. Free-floating DNA and RNA can yield information that previously required invasive ways of grabbing cells, such as taking a biopsy of a tumor or puncturing a pregnant woman’s belly to perform an amniocentesis. What’s changed is that it’s now easier to detect and sequence the small amounts of cell-free genetic material in the blood. In the last few years researchers have begun developing blood tests for cancer (by spotting the telltale DNA from tumor cells) and for prenatal screening of conditions like Down syndrome. The tests for these conditions rely on looking for genetic mutations in the DNA. RNA, on the other hand, is the molecule that regulates gene expression—how much of a protein is produced from a gene. By sequencing the free-floating RNA in the mother’s blood, Quake can spot fluctuations in the expression of seven genes that he singles out as associated with preterm birth. That lets him identify women likely to deliver too early. Once alerted, doctors can take measures to stave off an early birth and give the child a better chance of survival. The technology behind the blood test, Quake says, is quick, easy, and less than $10 a measurement. He and his collaborators have launched a startup, Akna Dx, to commercialize it. —Bonnie Rochman
2019
10 Breakthrough Technologies 2019 - How we’ll invent the future, by Bill Gates
MIT Technology Review
Predictions for the future: eight in ten Americans think that custom organ transplants will be a reality in the next 50 years, but just one in five think that humans will control the weather
Americans envision a range of probable
outcomes when asked for their own predictions
about whether or not some “futuristic”
inventions might become reality in the next half-century. Eight in ten believe that people needing
organ transplants will have new organs custom-built for them in a laboratory, but an equal number believe that control of the weather will remain outside the reach of science. And on other issues for example, the ability of computers to create art rivaling that produced by humans—the public is much more evenly split.
2014
US views of technology and the future - science in the next 50 years
Pew Research Center